go for the jugular

['dʒʌgjʊlə]

释义

专攻要害；射人先射马，擒贼先擒王
To exert an unrestrained, aggressive effort, especially by assailing an opponent's or victim's area of greatest vulnerability.

例句
Jane: Go Straight for the jugular.
Lisbon: Obviously, you struck a nerve.(The Mentalist)
简：真是专攻要害啊。
里斯本：显然，是你先命中要害了吧。（超感神探）